Readings

Readings for this course consist of the textbook, optional papers, and some suggested supplemental sources.

Textbook readings listed are in the course textbook:

Golan, D., et. al., eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Philadelphia, PA: Lippincott Williams and Wilkins, 2004. ISBN: 9780781746786.

The emphasis, particularly in long assignments like antibiotics, should be on mechanisms of action and principles of therapy rather than minutiae about individual drugs.

LEC # TOPICS TEXTBOOK READINGS optional PAPERS
1

Introduction

Receptors / Dose-Response

 pp. 3-26  
2

Pharmacokinetics I

Pharmacokinetics II

 pp. 27-43  
3

Interpreting Clinical Literature

Cholinergic Pharmacology

Case: Anticholinesterase

 pp. 55-106, and 724-725 Bernard, G. R., et. al. "Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis." The New England Journal of Medicine 344, no. 10 (2001): 699-709.
4

Drug Metabolism

Pharmacogenetics

Cases: Anticoagulation, Sulfasalazine

 pp. 45-54, 803-809, and 350-353  
5

Autonomic Pharmacology I

Autonomic Pharmacology II

Cases: Pheochromocytoma, Asthma

 pp. 205-228, 71-86, 107-120, and 695-708  
6

Local Anesthetics

Antidysrhythmics

Cases: Poison Control, Cocaine

 pp. 205-228, 121-136, 267-284, and 719-743 Buxton, Alfred E., et. al. "A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease." The New England Journal of Medicine 341, no. 25 (1999): 1882-1890.
7

Pharmacokinetics III

Antiinflammatory Drugs

Case: Glaucoma

 pp. 781-787, and 617-646 Weinblatt, Michael E., et. al. "A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor: Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate." The New England Journal of Medicine 340, no. 4 (1999): 253-259.

Edwards, David A., et. al. "Large Porous Particles for Pulmonary Drug Delivery." Science 276, no. 5320 (1997): 1868-1871.

Langer, Robert J. "New Methods of Drug Delivery." Science 249, no. 4976 (1990): 1527-1533.
8

Vasoactive Drugs I

Vasoactive Drugs II: Heart Failure

Cases: Pharmacogenetics, Thyroid Disease

 pp. 285-333, 375-399, and 415-424 Wing, Lindon M. H., et. al. "A Comparison of Outcomes with Angiotensin-converting-enzyme Inhibitors and Diuretics for Hypertension in the Elderly." The New England Journal of Medicine 348, no. 7 (2003): 583-592.

The Digitalis Investigation Group. "The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure." The New England Journal of Medicine 336, no. 8 (1997): 525-533.
9

Lipid Lowering Drugs

Cases: Placental Transfer, Gout

 pp. 357-374, 447, and 709-715 Knopp, Robert H. "Drug Treatment of Lipid Disorders." The New England Journal of Medicine 341, no. 7 (1999): 498-511.
10

Antihistamines

Immunosuppression for Solid Organ Transplantation

Cases: Antiemetics, Geriatric Pharmacology

 pp. 647-654, 683-694, and 667-681 Simons, F. Estelle R. "Advances in H1-Antihistamines." The New England Journal of Medicine 351, no. 21 (2004): 2203-2217.
11 Drug Development pp. 747-756, and 791-801 Lazo, John S., and Peter Wipf. "Combinatorial Chemistry and Contemporary Pharmacology." The Journal of Pharmacology and Experimental Therapeutics 298, no. 8 (2000): 705-709.
12

Neuropharmacology I: Drugs for Movement Disorders

Nitric Oxide

Cases: Placebo, Renal Failure

 pp. 161-178, and 40 Ichinose, Fumito, Jesse D. Roberts, Jr., and Warren M. Zapol. "Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential." Circulation 109, no. 25 (2004): 3106-3111.

Steudel, Wolfgang, William E. Hurford, and Warren M. Zapol. "Inhaled Nitric Oxide: Basic Biology and Clinical Applications." Anesthesiology 91, no. 4 (1990): 1090-1121.
13

Neuropharmacology II: Anxiolytics and Antidepressants

Neuropharmacology III: Anticonvulsants

Cases: Lithium, Alcohol

 pp. 139-159, 179-204, and 260-261  
14

Antimicrobials I

Antimicrobials II

Cases: Drug Allergy, Migraines

 pp. 493-504, 535-544, 565-578, and 603-613 Rodvold, Keith A. "Pharmacodynamics of Antiinfective Therapy: Taking What We Know to the Patient's Bedside." Pharmacotherapy 21, no. 11, Pt 2 (2001): 319S - 330S.
15

Chemotherapy I

Chemotherapy II

Cases: Folate, Oral Hypoglycemics

 pp. 505-554, and 457-471  
16

Opioids I

Opioids II

Cases: Cancer - Analgesia, Drug Abuse

 pp. 229-263 Kieffer, B. L. "Opioids: First Lessons from Knockout Mice." Trends in Pharmacological Sciences 20, no. 1 (1999): 19-26.

Some topics will reference additional sources, including:

Hardman, J. G., et. al., eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001. ISBN: 9780071354691.

Katzung, B., et. al., eds. Basic and Clinical Pharmacology. 9th ed. New York, NY: McGraw-Hill, 2003. ISBN: 9780071410922.

Katzung may be particularly helpful on the following topics:

  • Sulfasalazine and ulcerative colitis
  • Pheochromocytoma
  • Glaucoma
  • Teratogenesis and placental transfer
  • Antiemetics
  • Geriatric pharmacology
  • Placebo
  • Drug allergy
  • Migraines