| SES # | TOPICS | READINGS |
|---|---|---|
1 | Strategies for Biochemical Process Synthesis | |
2 | Biochemical Processing Overview | |
3 | Cell Disruption | Shutte, H., and M. R. Kula. "Cell Disruption and Isolation of Non-Secreted Products." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1993, pp. 505-526. ISBN: 9783527283132. |
4 | Solid-Liquid Separation: Centrifugation | Datar, R. V., and C. G. Rosen. "Cell and Cell Debris Removal: Centrifugation and Crossflow Filtration." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 469-486. ISBN: 9783527283132. |
5 | Chromatography |
Palmer, D. E., and R. V. Dove. "Ion Exchange Recovery of Proteins." In Comprehensive Biotechnology. Vol. 2, The Principles of Biotechnology: Engineering Considerations. Edited by C. L. Cooney, and A. E. Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 481-488. ISBN: 008032510. Yarmush, M. L., K. Antonsen, and D. M. Yarmush. "Molecular Sieve Chromatography." In Comprehensive Biotechnology. Vol. 2, The Principles of Biotechnology: Engineering Considerations. Edited by C. L. Cooney, and A. E. Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 489-505. ISBN: 008032510. Skoog, D. A., D. M. West, and F. J. Holler. "An Introduction to Chromatographic Methods." In Fundamentals of Analytical Chemistry. New York, NY: Saunders College Publishing, 1992, pp. 665-693. ISBN: 9780030749223. |
6 | Protein Refolding |
Cleland, J. L., and D. I. C. Wang. "In vitro Protein Refolding." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 527-555. ISBN: 9783527283132. Datar, R. V., T. Cartwright, and C. G. Rosen. "Process Economics of Animal Cell and Bacterial Fermentations - A Case Study Analysis of Tissue Plasminogen Activator." Bio/Technology 11, no. 3 (1993) 349-357. |
7 | Solid-Liquid Separation: Filtration | Ladisch, M. R. "Filtration." In Bioseparations Engineering: Principles, Practice, and Economics. New York, NY: John Wiley and Sons, 2001, pp. 36-47. ISBN: 9780471244769. |
8 | Membrane and Filtration Applications |
Datar, R. V., and C. G. Rosen. "Cell and Cell Debris Removal: Centrifugation and Crossflow Filtration." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 487-503. ISBN: 9783527283132. Tutunjian, R. S. "Ultrafiltration Processes in Biotechnology." In Comprehensive Biotechnology. Vol. 2, The Principles of Biotechnology: Engineering Considerations. Edited by C. L. Cooney, and A. E. Humphrey. Elmsford, NY: Pergamon Press Ltd., 1985, pp. 411-437. ISBN: 008032510. |
9 | Rotary Vacuum Filtration | |
10 | Process Synthesis, Analysis and Simulation |
Shuler, M. L., and F. Kargi. "Separation of Soluble Products." In Bioprocess Engineeing. Englewood Cliffs, NJ: Prentice Hall PTR, 1991, pp. 325-331. ISBN: 9780134782157. Kelly, B. D., and T. A. Hatton. "Protein Purification by Liquid-Liquid Extraction." In Biotechnology: A Multi-Volume Comprehensive Treatise. Vol. 3, Bioprocessing. Edited by G. Stephanopoulos. New York, NY: VCH Publishers, Inc., 1996, pp. 593-616. ISBN: 9783527283132. |
11 | Process Simulation |
Petrides, D., C. L. Cooney, and L. B. Evans. "An Introduction to Biochemical Process Design." In Chemical Engineering Problems in Biotechnology. Edited by M. L. Shuler. New York, NY: American Institute of Chemical Engineers, 1989, pp. 351-391. ISBN: 9780816904693. Ernst, S., et al. "Process Simulation for Recombinant Protein Production: Cost Estimation and Sensitivity Analysis for Heparinase I Expressed in Escherichia Coli." Biotechnology and Bioengineering 53, no. 6 (1997): 575-582. |
12 | Case Study in Innovation |
Bioprocess Design and Simulation Handout (PDF) (Courtesy of Steve Griffiths, PhD. Used with permission.) Insulin Case Study Petrides, D., E. Sapidou, and J. Calandranis. "Computer-Aided Process Analysis and Economic-Evaluation for Biosynthetic Human Insulin Production - A Case Study." Biotechnology and Bioengineering 48, no. 5 (1995): 529-541. |
13 | Process Validation |
