Readings

Course readings.
WEEK #	TOPICS	READINGS
1	Introduction See the Lecture Summary	no readings
2	Neuromuscular Junction (NMJ) Synapses, Miniature End-Plate Potentials (mEPPs), and Quantal Hypothesis See the Lecture Summary	Paper 1 Fatt, P., and B. Katz. "Spontaneous Subthreshold Activity at Motor Nerve Endings." J Physiol 117 (1952): 109-28. Paper 2 Orkand, R. K. "The Relation Between Membrane Potential and Contraction in Single Crayfish Muscle Fibres." J Physiol 161 (1962): 143-59.
3	Central Nervous System (CNS) Synapses and Glutamate Receptorst See the Lecture Summary	Paper 1 Herron, C. E., R. A. Lester, E. J. Coan, and G. L. Collingridge. "Frequency-Dependent Involvement of NMDA Receptors in the Hippocampus: A Novel Synaptic Mechanism." Nature 322 (1986): 265-8. Paper 2 Bekkers, J. M., and C. F. Stevens. "NMDA and non-NMDA Receptors are Co-localized at Individual Excitatory Synapses in Cultured Rat Hippocampus." Nature 341 (1989): 230-3.
4	CNS Synaptogenesis See the Lecture Summary	Paper 1 Wittenmayer, N., C. Körber, H. Liu, T. Kremer, F. Varoqueaux, E. R. Chapman, N. Brose, T. Kuner, and T. Dresbach. "Postsynaptic Neuroligin1 Regulates Presynaptic Maturation." PNAS 106 (2009): 13564-9. Paper 2 Tabuchi, K., J. Blundell, M. R. Etherton, R. E. Hammer, X. Liu, C. M. Powell, and T. C. Südhof. "A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice." Science 318 (2007): 71-6.
5	Synaptic Fusion and SNAREs See the Lecture Summary	Paper 1 Maximov, A., J. Tang, X. Yang, Z. P. Pang, and T. C. Südhof. "Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion." Science 323 (2009): 516-21. Paper 2 Xue, M., Y. Q. Lin, H. Pan, K. Reim, H. Deng, H. J. Bellen, and C. Rosenmund. "Tilting the Balance Between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis." Neuron 64 (2009): 367-80.
6	Synaptic Release, the Calcium Sensor Hypothesis, and Synaptotagmin See the Lecture Summary	Paper 1 Geppert, M., Y. Goda, R. E. Hammer, C. Li, T. W. Rosahl, C. F. Stevens, and T. C. Südhof. "Synaptotagmin I: a Major Ca2+ Sensor for Transmitter Release at a Central Synapse." Cell 79 (1994): 717-27. Paper 2 Yoshihara, M., and J. T. Littleton. "Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release." Neuron 5 (2002): 897-908.
7	Synaptic Plasticity: Presynaptic Pair-Pulse Changes See the Lecture Summary	Paper 1 Dittman, J. S., A. C. Kreitzer, and W. G. Regehr. "Interplay between Facilitation, Depression, and Residual Calcium at Three Presynaptic Terminals." J Neurosci 4 (2000): 1374-85. Paper 2 Liu, G., and R. W. Tsien. "Properties of Synaptic Transmission at Single Hippocampal Synaptic Boutons." Nature 6530 (1995): 404-8.
8	Field Trip to the Laboratory of Mark Bear See the Lecture Summary	no readings
9	Synaptic Plasticity: LTP See the Lecture Summary	Paper 1 Bliss, T. V., and T. Lomo. "Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path." J Physiol 2 (1973): 331-56. Paper 2 Isaac, J. T., R. A. Nicoll, and R. C. Malenka. "Evidence for Silent Synapses: Implications for the Expression of LTP." Neuron 2 (1995): 427-34.
10	Synaptic Plasticity: LTD See the Lecture Summary	Paper 1 Dudek, S. M., and M. F. Bear. "Homosynaptic Long-Term Depression in Area CA1 of Hippocampus and Effects of N-methyl-D-aspartate Receptor Blockade." PNAS 10 (1992): 4363-7. Paper 2 Kleppisch, T., V. Voigt, R. Allmann, and S. Offermanns. "G(alpha)q-deficient Mice Lack metabotropic Glutamate Receptor-Dependent Long-Term Depression but Show Normal Long-Term Potentiation in the Hippocampal CA1 Region." J Neurosci 14 (2001): 4943-8.
11	Synaptic Plasticity: STDP See the Lecture Summary	Paper 1 Bi, G. Q., and M. M. Poo. "Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type." J Neurosci 18, no. 24 (1998): 10464-72. Paper 2 Pawlak, V. and J. N. Kerr. "Dopamine Receptor Activation is Required for Corticostriatal Spike-Timing-Dependent Plasticity." J Neurosci 10 (2008): 2435-46.
12	Persistent Neuronal Activity and UP-States See the Lecture Summary	Paper 1 Shu, Y., A. Hasenstaub, and D. A. McCormick. "Turning on and off Recurrent Balanced Cortical Activity." Nature 6937 (2003): 288-93. Paper 2 Larimer, P., and B. W. Strowbridge. "Representing Information in Cell Assemblies: Persistent Activity Mediated by Semilunar Granule Cells." Nat Neurosci 2 (2010): 146-8.
13	Optogenetic Tools in Neuroscience See the Lecture Summary	Paper 1 Boyden, E. S., F. Zhang, E. Bamberg, G. Nagel, and K Deisseroth. "Millisecond-timescale, Genetically Targeted Optical Control of Neural Activity." Nat Neurosci 9 (2005): 1263-8. Paper 2 Petreanu, L., D. Huber, A. Sobczyk, and K. Svoboda. "Channelrhodopsin-2-assisted Circuit Mapping of Long-range Callosal Projections." Nat Neurosci 5 (2007): 663-8.
14	Oral Presentations See the Lecture Summary	no readings