| LEC # | TOPICS |
|---|---|
| 1 | Introduction (PDF) |
| 2 | Discovery of the Ubiquitin Conjugation System (PDF) |
| 3 | Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway (PDF) |
| 4 | Protein Degradation in Trafficking Membranes II: Endocytosis and lysosomal Degradation (PDF) |
| 5 | Role of Ubiquitination in Transcriptional Regulation (PDF) |
| 6 | Role of Ubiquitination in Cell Cycle Control and Programmed Cell Death (PDF) |
| 7 | Ubiquitin-like Proteins (PDF) |
| 8 | Functions of the Ubiquitin-Proteasome System in the Immune System (PDF) |
| 9 | Ubiquitin and Cancer (PDF) |
| 10 | Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases (PDF) |
| 11 | More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease (PDF) |
| 12 | Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome (PDF) |
| 13 | Potential Therapeutic Strategies in Ubiquitin-Related Diseases (PDF) |
| 14 | Oral Presentations Final Comments and Course Evaluation |
