1 00:00:10,950 --> 00:00:12,980 PROFESSOR: So as an aside, for those of you 2 00:00:12,980 --> 00:00:15,360 who have an understanding of probability 3 00:00:15,360 --> 00:00:17,850 theory and stochastic processes, let 4 00:00:17,850 --> 00:00:22,950 me just explain why it is valid to bound the main transmission 5 00:00:22,950 --> 00:00:26,520 rate in defining the indoor reproductive number when 6 00:00:26,520 --> 00:00:28,740 we might be more concerned about bounding 7 00:00:28,740 --> 00:00:31,360 the probability of a transmission. 8 00:00:31,360 --> 00:00:35,970 So let's let a capital T be a random variable which 9 00:00:35,970 --> 00:00:40,530 describes the random number of transmissions 10 00:00:40,530 --> 00:00:41,490 that occur in the room. 11 00:00:47,390 --> 00:00:54,690 And this is specifically for the case for one infector 12 00:00:54,690 --> 00:01:00,830 or infected person and n minus 1 susceptible. 13 00:01:04,349 --> 00:01:06,690 So again, the situation of the reproductive number where 14 00:01:06,690 --> 00:01:08,550 for every person that comes in we want to know 15 00:01:08,550 --> 00:01:09,960 is there going to be transmission, 16 00:01:09,960 --> 00:01:13,560 and typically, only one infected person would be seen. 17 00:01:13,560 --> 00:01:20,550 So this is a random variable, and let's let ft of n 18 00:01:20,550 --> 00:01:23,460 be the probability density function that 19 00:01:23,460 --> 00:01:27,810 gives the probability of little n transmissions. 20 00:01:27,810 --> 00:01:37,590 And then we can define the risk of a transmission, the risk 21 00:01:37,590 --> 00:01:47,229 of at least one transmission, as the probability 22 00:01:47,229 --> 00:01:50,170 that this random variable takes on a value, which 23 00:01:50,170 --> 00:01:52,190 is greater than or equal to 1. 24 00:01:52,190 --> 00:01:52,690 OK. 25 00:01:52,690 --> 00:01:55,450 Well, in terms of the probability density function 26 00:01:55,450 --> 00:02:05,200 then, that would be a sum from 1 to infinity of the ft event, 27 00:02:05,200 --> 00:02:05,710 basically. 28 00:02:05,710 --> 00:02:07,720 So we're just adding the probabilities 29 00:02:07,720 --> 00:02:12,730 that we're not seeing a transmission to those-- 30 00:02:12,730 --> 00:02:16,870 or possible transition to those different numbers of people. 31 00:02:16,870 --> 00:02:18,660 Now I'd like to do a little calculation 32 00:02:18,660 --> 00:02:21,620 to get an upper bound on this quantity. 33 00:02:21,620 --> 00:02:24,490 So we can say that this is less than 34 00:02:24,490 --> 00:02:28,280 or equal to the sum from n equals 1 35 00:02:28,280 --> 00:02:33,470 to infinity of n ft of n. 36 00:02:33,470 --> 00:02:35,910 Now, this is just a mathematical trick here. 37 00:02:35,910 --> 00:02:41,560 So n refers to the natural numbers 1, 2, 3, 4, et cetera. 38 00:02:41,560 --> 00:02:43,310 Those are all positive numbers and they're 39 00:02:43,310 --> 00:02:44,600 all greater than or equal to 1. 40 00:02:44,600 --> 00:02:46,520 So if I take 1 in this expression over here 41 00:02:46,520 --> 00:02:48,140 and replace it with little n, I'm 42 00:02:48,140 --> 00:02:51,110 only increasing the value of that sum, because also, 43 00:02:51,110 --> 00:02:55,910 this ft is a probability density that has to be positive. 44 00:02:55,910 --> 00:02:58,790 And then now I can also say that this is actually 45 00:02:58,790 --> 00:03:03,740 equal to throwing in n equals 0, because that is a term that 46 00:03:03,740 --> 00:03:05,180 is actually identically 0. 47 00:03:05,180 --> 00:03:08,790 So I can change the summation. 48 00:03:08,790 --> 00:03:11,930 And then by definition here, this thing 49 00:03:11,930 --> 00:03:15,560 is the expected value of the number of transmissions, 50 00:03:15,560 --> 00:03:18,079 because I'm summing the number of transmissions 51 00:03:18,079 --> 00:03:20,380 little n times the probability of that event occurring. 52 00:03:20,380 --> 00:03:22,829 So that is the definition of the average. 53 00:03:22,829 --> 00:03:29,420 So what we're seeing here is that the risk of a transmission 54 00:03:29,420 --> 00:03:33,800 is rigorously bounded above by the expected 55 00:03:33,800 --> 00:03:35,900 number of transmissions. 56 00:03:35,900 --> 00:03:41,810 And so therefore, if we require that this is less than epsilon, 57 00:03:41,810 --> 00:03:45,780 our risk tolerance that we've just introduced, 58 00:03:45,780 --> 00:03:58,090 this is a conservative bound on the true risk, which let's 59 00:03:58,090 --> 00:03:59,690 say here is defined by rt. 60 00:03:59,690 --> 00:04:02,950 So if your goal is to control the probability of having 61 00:04:02,950 --> 00:04:04,720 at least one transmission, so basically 62 00:04:04,720 --> 00:04:07,150 to ensure that no transmissions occur, 63 00:04:07,150 --> 00:04:10,030 then you would do well to bound the expected number 64 00:04:10,030 --> 00:04:12,160 of transmissions, because that's an upper bound. 65 00:04:12,160 --> 00:04:16,029 It can also be shown that as epsilon 66 00:04:16,029 --> 00:04:19,209 goes to 0, so we're talking about very low probabilities 67 00:04:19,209 --> 00:04:23,360 of transmission, and oftentimes that is the case, 68 00:04:23,360 --> 00:04:28,140 then rt is asymptotically the same as the expected 69 00:04:28,140 --> 00:04:29,140 number of transmissions. 70 00:04:29,140 --> 00:04:33,010 So this overall risk of a transmission and the expected 71 00:04:33,010 --> 00:04:34,420 number are the same. 72 00:04:34,420 --> 00:04:36,130 And in fact, that's one way to understand 73 00:04:36,130 --> 00:04:38,590 sort of even the definition of a probability 74 00:04:38,590 --> 00:04:41,590 in terms of an expected number of events. 75 00:04:41,590 --> 00:04:43,450 And we are typically thinking of cases where 76 00:04:43,450 --> 00:04:45,880 epsilon is much less than 1. 77 00:04:45,880 --> 00:04:48,940 So for those of you that have some background in probability, 78 00:04:48,940 --> 00:04:51,310 you may recognize that what I've just done here 79 00:04:51,310 --> 00:04:55,000 is an example of a much more general result, which 80 00:04:55,000 --> 00:04:56,870 is called Markov's Inequality. 81 00:05:02,920 --> 00:05:04,860 So now we can safely proceed by continuing 82 00:05:04,860 --> 00:05:09,410 to work with average values of all the quantities of interest.